Cox regression factor | Level of factor | Total No. of participants (No. with LOA) | Median age, years, at LOA (95% CI) | HR (95% CI) | p Value |
---|---|---|---|---|---|
DMD mutation | Other deletions | 315 (92) | 11.03 (10.29, 11.77) | 1b | – |
Nonsense mutations | 174 (31) | 13.29 (11.24, 15.34) | 0.66 (0.44, 0.99) | 0.045a | |
Exon 44 amenable skipping | 81 (18) | 13.34 (10.53, 16.15) | 0.56 (0.33, 0.94) | 0.029a | |
Exon 45 amenable skipping | 101 (31) | 10.18 (9.79, 10.57) | 1.31 (0.87, 1.97) | 0.193 | |
Exon 51 amenable skipping | 146 (31) | 10.72 (9.90, 11.54) | 1.08 (0.72, 1.63) | 0.709 | |
Exon 53 amenable skipping | 150 (40) | 11.03 (10.06, 12.00) | 1.13 (0.78, 1.65) | 0.508 | |
GC drug | Untreated (or treated < 1 month) | 326 (111) | 10.23 (9.97, 10.49) | 1b | – |
Deflazacort | 65 (4) | 13.95 (11.80, 16.10) | 0.06 (0.02, 0.19) | < 0.001 | |
Prednisone or prednisolone | 465 (146) | 12.02 (11.40, 12.64) | 0.40 (0.31, 0.52) | < 0.001 |