Table 1 Comparison of the clinical manifestations of ATTR and COVID-19

Cardiovascular

HF, rhythm disturbances, conduction block, dyspnea, syncope, palpitations, elevated biomarkers, thromboembolism

HF, myocardial injury, myocarditis, acute coronary syndromes, palpitations, dyspnea, elevated biomarkers, thromboembolism

[11, 14, 17, 26, 30, 63, 64, 66]

Gastrointestinal

Diarrhea, constipation, loss of appetite, nausea

Diarrhea, loss of appetite, nausea/vomiting, gastroenteritis

[6, 9, 26, 29, 91, 92]

Hematologic and Immunologic

Increased pro-inflammatory cytokines, increased propensity to left atrial thrombosis

Cytokine storm, venous thrombosis, lymphopenia, venous/arterial thromboembolism, coagulopathy, microangiopathy

[15, 16, 20,21,22, 40, 56]

Musculoskeletal

CTS, spinal stenosis, trigger finger, shoulder, knee and hip surgery

Arthralgia, myalgias

[11, 31, 81, 103, 104]

Renal

Proteinuria, renal failure

AKI, ATN

[26, 30, 40, 48, 93, 94]

Neurologic

 CNS: headache, ataxia, seizures, stroke-like episodes

Headache, dizziness, seizures, mental status changes, muscle pain, stroke, neuropathy (eg, AIDP), myopathy, myelitis, anosmia, hypogeusia, dysgeusia

[12, 26, 30, 32, 34, 70,71,72, 75,76,77, 105, 106]

 Peripheral neuropathy: numbness/tingling in hands and feet, neuropathic pain, walking disability, loss of balance

Autonomic neuropathy: urinary retention and incontinence; erectile dysfunction; orthostatic hypotension; gastrointestinal manifestations

Pulmonary

 Impairment from alveolar-septal amyloidosis

Cough, shortness of breath, pneumonia, ARDS

[1, 4, 5, 44, 45, 47, 48]

 Pulmonary hypertension due to left-sided heart disease

Other/Constitutional

Unintentional weight loss

Fever, fatigue

[5, 7, 26]