Table 1 Comparison of the clinical manifestations of ATTR and COVID-19
From: ATTR amyloidosis during the COVID-19 pandemic: insights from a global medical roundtable
| ATTR | COVID-19 | References | |
|---|---|---|---|
| Cardiovascular | HF, rhythm disturbances, conduction block, dyspnea, syncope, palpitations, elevated biomarkers, thromboembolism | HF, myocardial injury, myocarditis, acute coronary syndromes, palpitations, dyspnea, elevated biomarkers, thromboembolism | [11, 14, 17, 26, 30, 63, 64, 66] |
| Gastrointestinal | Diarrhea, constipation, loss of appetite, nausea | Diarrhea, loss of appetite, nausea/vomiting, gastroenteritis | [6, 9, 26, 29, 91, 92] |
| Hematologic and Immunologic | Increased pro-inflammatory cytokines, increased propensity to left atrial thrombosis | Cytokine storm, venous thrombosis, lymphopenia, venous/arterial thromboembolism, coagulopathy, microangiopathy | [15, 16, 20,21,22, 40, 56] |
| Musculoskeletal | CTS, spinal stenosis, trigger finger, shoulder, knee and hip surgery | Arthralgia, myalgias | [11, 31, 81, 103, 104] |
| Renal | Proteinuria, renal failure | AKI, ATN | [26, 30, 40, 48, 93, 94] |
| Neurologic | CNS: headache, ataxia, seizures, stroke-like episodes | Headache, dizziness, seizures, mental status changes, muscle pain, stroke, neuropathy (eg, AIDP), myopathy, myelitis, anosmia, hypogeusia, dysgeusia | [12, 26, 30, 32, 34, 70,71,72, 75,76,77, 105, 106] |
| Peripheral neuropathy: numbness/tingling in hands and feet, neuropathic pain, walking disability, loss of balance | |||
| Autonomic neuropathy: urinary retention and incontinence; erectile dysfunction; orthostatic hypotension; gastrointestinal manifestations | |||
| Pulmonary | Impairment from alveolar-septal amyloidosis | Cough, shortness of breath, pneumonia, ARDS | [1, 4, 5, 44, 45, 47, 48] |
| Pulmonary hypertension due to left-sided heart disease | |||
| Other/Constitutional | Unintentional weight loss | Fever, fatigue | [5, 7, 26] |