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Table 2 Lesions characteristics, treatment and outcomes of EGPA patients with CNS involvement

From: Clinical features of central nervous system involvement in patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study in China

ID Sex/age Lesions features Lesions location Induction therapy Intrathecal injectionsa FU, months Outcomes
1 F/39 Ischemic infarctions Multiple MP 80 mg qd N 1 death
2 F/46 Ischemic infarctions Right semiovale centers Pred 80 mg qd + CYC N 84 remissionb
3 M/49 Ischemic infarctions; PRES Multiple, subacute cerebral infarcts in left basal ganglia MP pulse + IVIG + CYC DXM *3 72 remission
4 M/49 Ischemic infarctions Basal ganglia MP pulse N 48 remissionb
5 F/71 Spinal cord involvement Thoracic spinal cord MP 40 mg qd N 24 remission
6 M/64 Ischemic infarctions; PRES Right semiovale centers MP 80 mg qd + IVIG + CYC N 46 remission
7 M/52 Ischemic infarctions; PRES; ataxia; Bilateral basal ganglia; cerebellar ataxia MP 24 mg qd + CYC + AZA DXM *1 + MTX *4 36 remissionb
8 F/72 Ischemic infarctions Multiple lesions in cerebrum MP 160 mg qd N 20 remissionb
9 F/49 HCP Cerebral falx MP pulse N 15 remissionb
10 F/45 Ischemic infarctions; PRES Under bilateral frontal and parieto-occipital cortex Pred 40 mg qd + CYC N 42 remissionb
11 F/47 HCP Bilateral brain MP pulse DXM *5 132 remission
12 M/57 Medulla oblongata and spinal cord lesions Medulla oblongata and cervical spinal cord MP pulse N 17 remission
13 F/63 Ischemic infarctions Right basal ganglia and white matter MP pulse N 12 remission
14 F/55 Intracranial hemorrhages; PRES Right frontal–temporal lobe MP pulse + Plasma change + CYC N 1 death
15 M/46 Ischemic infarctions Multiple lesions in cerebrum MP 40 mg qd + CYC N 4 remission
16 M/25 Medulla oblongata and spinal cord involvement Medulla oblongata and thoracic spinal cord Pred 17.5 mg qd + CYC N 76 remission
17 M/34 Intracranial hemorrhages Subarachnoid space Pred 50 mg qd + CYC N 9 remissionb
18 M/41 Ischemic infarctions; PRES; medulla oblongata lesions; ataxia Subcortex of bilateral frontal parietal lobe; right side of medulla oblongata; cerebellum MP pulse + IVIG N 20 remission
19 M/64 Ischemic infarctions; intracranial hemorrhages; PRES Infarcts in cortex and white matter; cerebral hemorrhages in left basal ganglia, cortex, subcortex and the sulci MP pulse DXM *1 6 remission
  1. Sex, F-female, M-male; FU, follow-up duration; MP, methylprednisolone; Pred, prednisone; IVIG, intravenous immunoglobulin; CYC, cyclophosphamide; PRES, posterior reversible encephalopathy syndrome; HCP, hypertrophic cranial pachymeningitis
  2. a“N” indicates no intrathecal injections were used during the follow-up, and the number after the asterisk refers to the number of intrathecal injections in this column; DXM, Dexamethasone; MTX, methotrexate; AZA, azathioprine
  3. bRelapse during glucocorticoid reduction;
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