Fig. 3

DUX4-FL protein. This protein contains 424 amino acids and is expected to have well-defined tertiary structures in each of the two DNA-binding homeodomains (amino acids 19–79 and 94–154) and in the most C-terminal region (amino acids ∼ 365–424). The C-terminal region includes the transcription-activating domain (TAD) and a p300-binding domain. The region between the second homeodomain and the C-terminal domain (amino acids ∼ 155–364) is predicted to be disordered. The protein contains a potential nine amino acid TAD (9aaTAD) at amino acids 371–379 (classified as a 92% match) [74]