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Table 1 Demographic and clinical characteristics of the subjects

From: B cell‐activating factors in autoimmune pulmonary alveolar proteinosis

    APAP    Healthy Volunteer   Disease Control
Characteristics N % Median (I.Q. range )      or Mean ± SD N % Median (I.Q. range )        or Mean ± SD N % Median (I.Q. range )        or Mean ± SD
Age – years 110   55.8 ± 13.4 34   51.4 ± 6.5 13   49.2 (29.7–55.5)
Gender          
 Female 33 30   21 61.8   4 30.8  
 Male 77 70   13 38.2   9 69.2  
Onset of symptom – years 110   53.0 ± 13.3       
Symptoms          
 Dyspnea 82 74.5        
 Cough 54 49.1        
 Sputum 39 35.5        
Dust exposure          
 Yes 45 40.9        
 No 65 59.1        
Smoking          
 Current 28 25.5   4 11.8   3 23.1  
 Ex 43 39   12 35.3   5 38.5  
 Never 39 35.5   16 47.1   2 15.4  
 Unknown 0 0   2 5.9   3 23.1  
Pulmonary function          
 VC, % predicted 98   90.3 ± 22.9     13   91.3 (79.8–111.0)
 FVC, % predicted 98   88.9 ± 24.0     13   91.3 (79.7–109.1)
 FEV1.0, % predicted 94   95.3 ± 25.0     13   79.0 (64.1–94.6)
 DLco, % predicted 97   59.1 (45.6–75.9)     13   49.4 (37.6–80.3)
 PaO2 75   68.8 ± 15.3       
Serum biomarkers          
 KL-6, U/L 108   3799.5 (1601.0–8787.5)     13   328.0 (237.5–917.0)
 SP-D, ng/ml 106   183.9 (120.6–311.5)     12   65.5 (39.0–134.8)
 SP-A, ng/ml 81   96.7 (62.5–151.4)     13   40.1 (31.3–67.5)
 LDH, IU/L 108   263.5 (217.8–339.8)       185.0 (144.0–219.5)
 Anti-GM-CSF autoantibody, µg/ml 110   40.5 (17.1–71.8)       
  1. APAP, autoimmune pulmonary alveolar proteinosis; IQR, interquartile range; SD, standard deviation; VC, vital capacity; FVC, forced expiratory volume; FEV1, forced expiratory volume in 1 s; DLco, diffusion capacity for carbon monoxide; PaO2, arterial partial pressure of oxygen; KL-6, Krebs von den Lungen-6; SP-D, surfactant protein-D; SP-A, surfactant protein-A; LDH; lactate dehydrogenase; GM-CSF, granulocyte-macrophage colony-stimulating factor. Data are expressed as the median (IQR) or mean ± SD