Epidemiology of systemic sclerosis: a multi-database population-based study in Tuscany (Italy)

Table 1 SSc-related complications and comorbidities in inpatient population in the 2003–2017 period: number of cases and percentages by sex, referred to the inpatient population and test to assess statistically significant sex differences

		Cases	%	pr-test
Heart and Circulation^a	M	55	45.5	0.26
	F	312	40.1
	Total	367	40.8
Acute myocardial infarction	M	5	4.1	0.18
	F	16	2.1
	Total	21	2.3
Subarachnoid and intracerebral haemorrhage	M	1	0.8	0.83
	F	8	1.0
	Total	9	1.0
Ischemic stroke events	M	2	1.7	0.72
	F	10	1.3
	Total	12	1.3
Congestive heart failure	M	16	13.2	0.46
	F	85	10.9
	Total	101	11.2
Malignant essential hypertension	M	0	0.0	0.23
	F	9	1.2
	Total	9	1.0
Gangrene	M	2	1.7	0.48
	F	22	2.8
	Total	24	2.7
Chronic ulcer of skin (except pressure ulcer)	M	28	23.1	0.42
	F	155	19.9
	Total	183	20.4
Lung^b	M	53	43.8	0.06
	F	272	35.0
	Total	325	36.2
PAH	M	5	4.1	0.33
	F	50	6.4
	Total	55	6.1
Lung involvement	M	38	31.4	0.39
	F	215	27.6
	Total	253	28.1
Pulmonary fibrosis	M	10	8.3	0.04
	F	31	4.0
	Total	41	4.6
Pneumonia	M	16	13.2	0.002
	F	44	5.7
	Total	60	6.7
Pulmonary embolism	M	0	0.0	–
	F	13	1.7
	Total	13	1.4
Kidney^c	M	5	4.1	0.91
	F	34	4.4
	Total	39	4.3
Chronic kidney disease	M	1	0.83	0.48
	F	13	1.67
	Total	14	1.56
Acute renal failure	M	4	3.3	0.95
	F	25	3.2
	Total	29	3.2
Gastrointestinal tract^d	M	5	4.1	0.56
	F	24	3.1
	Total	29	3.2
Hemorrhage of gastrointestinal tract	M	0	0.0	–
	F	4	0.5
	Total	4	0.4
Intestinal obstruction (without hernia)	M	5	4.1	0.39
	F	21	2.7
	Total	26	2.9
Metabolism^e	M	43	35.5	0.0001
	F	153	19.7
	Total	196	21.8
Diabetes mellitus	M	19	15.7	0.04
	F	75	9.6
	Total	94	10.5
Gout	M	32	26.4	0.0001
	F	98	12.6
	Total	130	14.5
Malignant neoplasms	M	18	14.9	0.55
	F	100	12.9
	Total	118	13.1

%, percentages referred to the total of the inpatient population; pr-test, p-value of the test of difference of proportion, a p-value < 0.05 (in bold) indicates a statistically significant difference in SSc-related complications between males and females
^aCases with at least one occurrence of the following complications or comorbidities: acute myocardial infarction, subarachnoid and intracerebral haemorrhage, ischemic stroke events, congestive heart failure, malignant essential hypertension, gangrene, and chronic ulcer of skin
^bCases with at least one occurrence of the following complications or comorbidities: PAH, lung involvement in systemic sclerosis, pneumonia, and pulmonary embolism
^cCases with at least one occurrence of the following complications or comorbidities: chronic kidney disease and acute renal failure
^dCases with at least one occurrence of the following complications or comorbidities: haemorrhage of gastrointestinal tract and intestinal obstruction
^eCases with at least one occurrence of the following complications or comorbidities: diabetes mellitus and gout

ISSN: 1750-1172