Table 1 Symptoms reported by organ system
Symptoms reported by organ system | ATTR-CM | ATTR-PN |
|---|---|---|
Cardiac | ||
Arrhythmia | ✓ | ✓ |
Atrial Fibrillation | ✓ | |
Enlarged heart | ✓ | |
Fluid retention/Swelling | ✓ | |
“Hearing” own heartbeat | ✓ | |
Increased fatigue with altitude | ✓ | |
Intolerance to activity | ✓ | |
Orthostatic hypotension | ✓ | |
Passing out/Fainting | ✓ | |
Shortness of breath | ✓ | |
Gastro-intestinal | ||
Abdominal pain | ✓ | |
Bloating | ✓ | |
Bowel problems | ✓ | |
Changes in taste of food/loss of taste in food | ✓ | |
Constipation | ✓ | ✓ |
Diarrhea (chronic) | ✓ | |
Feeling full quickly | ✓ | |
Loss of appetite | ✓ | |
Low esophageal motility/ "slow digestion" | ✓ | |
Pasty feeling in mouth | ✓ | |
Upset stomach | ✓ | |
Vomiting | ✓ | |
Weight loss | ✓ | ✓ |
Integumentary | ||
Night sweats | ✓ | |
Rash | ✓ | |
Musculoskeletal | ||
Back pain | ✓ | |
Balance when walking | ✓ | |
Bi lateral carpal tunnel | ✓ | |
Clumsiness/dropping tools | ✓ | |
Contraction of fingers | ✓ | |
Heaviness in legs | ✓ | |
Inability to exercise | ✓ | |
Loss of muscle mass | ✓ | |
Loss of muscle tone | ✓ | ✓ |
Loss of stability | ✓ | |
Muscle twitching, cramps and spasms | ✓ | ✓ |
Weakness | ✓ | |
Weakness/knees buckling | ✓ | |
Neurological | ||
Burning sensation in feet and hands | ✓ | |
Cold skin, hands, feet | ✓ | |
Decreased sensitivity | ✓ | |
Dizziness | ✓ | ✓ |
Dry eyes | ✓ | |
Erectile dysfunction | ✓ | ✓ |
Fatigue | ✓ | ✓ |
General malaise | ✓ | ✓ |
Hearing loss | ✓ | |
Heat intolerance | ✓ | |
Increased sweating | ✓ | |
Lower back pain | ✓ | |
Memory loss | ✓ | |
No sensation with full bladder | ✓ | |
Numbness in hands | ✓ | |
Pain in feet | ✓ | |
Pins and needles | ✓ | |
Reduced sexual drive | ✓ | |
Sensitive to touch/unusual burning | ✓ | ✓ |
Urinary incontinence (nocturia) | ✓ | |
Urinary retention | ✓ | |
Vision impairment | ✓ | ✓ |
Psychiatric | ||
Depression | ✓ | ✓ |
Mood changes | ✓ | ✓ |
Sleep disorders/Insomnia | ✓ |