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Table 1 Symptoms reported by organ system

From: Patient and family experience with transthyretin amyloid cardiomyopathy (ATTR-CM) and polyneuropathy (ATTR-PN) amyloidosis: results of two focus groups

Symptoms reported by organ system ATTR-CM ATTR-PN
Cardiac   
Arrhythmia
Atrial Fibrillation  
Enlarged heart  
Fluid retention/Swelling  
“Hearing” own heartbeat  
Increased fatigue with altitude  
Intolerance to activity  
Orthostatic hypotension  
Passing out/Fainting  
Shortness of breath  
Gastro-intestinal   
Abdominal pain  
Bloating  
Bowel problems  
Changes in taste of food/loss of taste in food  
Constipation
Diarrhea (chronic)  
Feeling full quickly  
Loss of appetite  
Low esophageal motility/ "slow digestion"  
Pasty feeling in mouth  
Upset stomach  
Vomiting  
Weight loss
Integumentary   
Night sweats  
Rash  
Musculoskeletal   
Back pain  
Balance when walking  
Bi lateral carpal tunnel  
Clumsiness/dropping tools  
Contraction of fingers  
Heaviness in legs  
Inability to exercise  
Loss of muscle mass  
Loss of muscle tone
Loss of stability  
Muscle twitching, cramps and spasms
Weakness  
Weakness/knees buckling  
Neurological   
Burning sensation in feet and hands  
Cold skin, hands, feet  
Decreased sensitivity  
Dizziness
Dry eyes  
Erectile dysfunction
Fatigue
General malaise
Hearing loss  
Heat intolerance  
Increased sweating  
Lower back pain  
Memory loss  
No sensation with full bladder  
Numbness in hands  
Pain in feet  
Pins and needles  
Reduced sexual drive  
Sensitive to touch/unusual burning
Urinary incontinence (nocturia)  
Urinary retention  
Vision impairment
Psychiatric   
Depression
Mood changes
Sleep disorders/Insomnia