Fig. 2

Optimal ROC curve for the clinical diagnostic score showing the maximal area under the curve (AUC) obtained for the score defined in Table 2. Optimal sensitivity and specificity on this curve are 95.7% and 86.4% respectively (a), corresponding to a threshold of 8.5 for the diagnostic score (b). Solid lines draw the thresholds of 7 and 10 that were chosen to distinguish low/moderate/high likelihood for CS diagnosis based on positive predictive value (not shown)