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Table 9 Protein levels in human and mouse CSF

From: Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways

Protein

Human MLIV/Con

Mcoln1−/− versus Mcoln1±

Ratio

Fold-change

A1bg

0.11

− 26.0***

Lysosomal proteins

Epdr1

n.d

2.62***

Ppt1

1.39

7.63***

Man2b1

n.d

3.23*

Man2b2

n.d

6.95**

Gns

 + 

6.72*

Tpp1

0.70

5.73*

Lamp1

n.d

2.88*

Ctsz

3.17

2.25**

Calbindin-related proteins

Calb1

0.46

25.21***

Calb2

 + 

10.41***

Pcp4

 + 

12.7***

  1. Protein levels were measured in the CSF from the MLIV patient and from 1-, 2-, 3- and 7-month-old Mcoln1−/− versus Mcoln1± mice (n = 3–4 for each time point). Changes are indicated by + for a protein that was detected only in the MLIV sample and by n.d. when it could not be detected in either sample.* p < 0.05, ** p < 0.01, *** p < 0.001