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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: A recurrent ABCC2 p.G693R mutation resulting in loss of function of MRP2 and hyperbilirubinemia in Dubin-Johnson syndrome in China

Fig. 2

The MRP2 p.G693R mutant showed decreased expression and mislocalization in three cell lines in vitro. a Western blotting demonstrated significantly decreased expression of MRP2 in three cell lines expressing the p.G693R mutant compared with those expressing wild-type MRP2. **P < 0.05. b Immunofluorescence assay showed the mislocalization of the MRP2 p.G693R mutant, which was predominantly retained in the cytoplasm rather than the cell surface

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172