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Table 1 The demographic, clinical and laboratorial characteristics of the patients included in the study

From: Development and validation of the prognostic value of ferritin in adult patients with Hemophagocytic Lymphohistiocytosis

CharacteristicsTest Cohort (n = 161)Validation Cohort (n = 68)All (n = 229)P-value
IAHS
(n = 57)
MAHS
(n = 39)
MCTD
(n = 8)
Mixed
(n = 27)
Unclear
(n = 30)
IAHS
(n = 17)
MAHS
(n = 14)
Mixed
(n = 23)
Unclear
(n = 14)
Test cohort (n = 161)Validation cohort (n = 68)
General
Gender (male/female), n37/2024/153/516/1113/1710/79/514/95/993/6838/300.793
Median age (range), y52(18–88)46(18–68)44(19–59)51(22–78)44(18–74)49(20–86)59(21–76)62(19–88)54(47–78)49(18–88)55(19–88)0.022
Clinical features
Fever,n53377253016132213152641.000
Mean Tmax,°C39.439.439.739.439.439.139.239.339.439.439.30.109
Hepatomegaly8906920243280.140
Splenomegaly141501012264551170.312
Lymph node enlargement81118712423590.136
Rash54421031212570.297
Jaundice135157312431100.412
Edema105356526429170.228
Bone marrow Hemophagocytosis41/4533/375/717/2624/2614/1411/1219/1910/12120/14154/570.060
Laboratory data
Ferritin ≥ 500 μg/L49/5433/378/823/2429/3016/1612/1422/2311/12142/15361/651.000
EBV DNA copies (+)23/4511/280/712/260/256/95/1010/151/946/13122/430.061
FIB < 1.5 g/L15/5111/331/64/243/274/144/133/202/834/14113/550.944
ANC < 1.0 × 109/L12/569/360/87/252/293/175/147/234/1330/15419/670.144
Hb < 90 g/L25/5619/381/812/256/304/176/149/236/1363/15725/670.693
Platelets
<100 × 109/L
47/5631/394/821/2521/3015/1712/1415/2310/13124/15852/670.885
ALT > 40 U/L43/5629/387/813/2521/2910/167/1417/239/13113/15643/660.278
AST > 40 U/L44/5630/387/818/2522/2812/1611/1417/239/13121/15549/660.537
LDH > 271 U/L47/5635/397/821/2526/2912/1612/1321/2312/12136/15757/640.621
DB > 6.8 μmol/L31/5618/372/818/2514/2910/164/1315/239/1283/15539/660.448
TG > 3 mmol/L6/5613/351/88/254/292/162/135/227/1232/15316/630.471
Albumin < 40 g/L54/5635/358/824/2529/3016/1612/1323/2311/12150/15462/641.000
Ca2+ < 2.20 mmol/L48/5626/348/822/2524/2916/1714/1421/2313/13128/15264/670.019
  1. ALT Alanine aminotransferase, ANC Absolute neutrophil count, AST Aspartate aminotransferase, Ca2+ Calcium, DB Direct bilirubin, EBV Epstein Barr virus, FIB Fibrinogen, HB Hemoglobin, IAHS Infection-associated HLH, MAHS Malignancy-associated HLH, LDH Lactate dehydrogenase, MCTD Mixed connective tissue disease, Mixed Mixed cause HLH, TG Triglyceride, Unclear Unknown underlying diseases; *Comparison with test cohort and validation cohort