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Table 4 Comparisons between mean carotid measures of Morquio A patients treated with Enzyme Replacement Therapy (ERT) and those not treated with ERT

From: Abnormally increased carotid intima media-thickness and elasticity in patients with Morquio A disease

Score

Covariate

Difference (95% CI)

P-value

cIMT

ERT (vs. not)

0.00 (āˆ’0.03, 0.03)

0.916

(mm)

Female (vs. Male)

āˆ’0.01 (āˆ’0.05, 0.02)

0.402

Ā 

Age (per 10ā€‰yr)

0.01 (āˆ’ā€‰0.01, 0.02)

0.587

Ā 

Height (per 10ā€‰cm)

0.00 (āˆ’0.01, 0.00)

0.408

cCSD

ERT (vs. not)

āˆ’2.20 (āˆ’8.91, 4.51)

0.520

(%)

Female (vs. Male)

0.14 (āˆ’8.06, 8.34)

0.973

Ā 

Age (per 10ā€‰yr)

1.31 (āˆ’4.23, 6.86)

0.643

Ā 

Height (per 10ā€‰cm)

āˆ’2.98 (āˆ’5.38, āˆ’0.58)

0.015

cCSC1

ERT (vs. not)

āˆ’0.03 (āˆ’ā€‰0.08, 0.02)

0.279

(mm2

Female (vs. Male)

āˆ’0.03 (āˆ’ā€‰0.09, 0.04)

0.465

Ā· mm Hgāˆ’1)

Age (per 10ā€‰yr)

0.01 (āˆ’0.03, 0.05)

0.686

Ā 

Height (per 10ā€‰cm)

āˆ’0.02 (āˆ’ā€‰0.04, āˆ’ā€‰0.01)

0.005

cIEM

ERT (vs. not)

136.86 (2.44, 271.29)

0.046

(mm Hg)

Female (vs. Male)

14.88 (āˆ’ā€‰145.24, 175.00)

0.855

Ā 

Age (per 10ā€‰yr)

34.26 (āˆ’ā€‰105.85, 174.38)

0.632

Ā 

Height (per 10ā€‰cm)

130.82 (80.41, 181.23)

<ā€‰0.001

  1. Analyses are adjusted for sex, age, and height. Significant comparisons are highlighted in bold. Height is a significant influence upon cCSD, cCSC1, and cIEM