Skip to main content

Table 5 Diagnostic utility measures for serum ALP level thresholds

From: Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?

ALPa levelsSensitivityEspecificityPPVNVP+LR-LR
<  20 IU/L15.4%100%100%57.7%Infinity0.85
< 25 IU/L43.6%97.8%94.4%66.7%19.80.58
< 30 IU/L82.1%44.4%56.1%74.1%1.480.4
<  35 IU/L97.4%4.4%46.9%66.7%1.020.59
  1. PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, ALP Alkaline phosphatase