Table 5 Diagnostic utility measures for serum ALP level thresholds
From: Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?
ALPa levels | Sensitivity | Especificity | PPV | NVP | +LR | -LR |
|---|---|---|---|---|---|---|
< 20 IU/L | 15.4% | 100% | 100% | 57.7% | Infinity | 0.85 |
< 25 IU/L | 43.6% | 97.8% | 94.4% | 66.7% | 19.8 | 0.58 |
< 30 IU/L | 82.1% | 44.4% | 56.1% | 74.1% | 1.48 | 0.4 |
< 35 IU/L | 97.4% | 4.4% | 46.9% | 66.7% | 1.02 | 0.59 |