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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes

Fig. 3

Schematic representation of FGFR2 signaling through the Ras/Raf/MAPK pathway. FGFR2 and B-Raf were found 2 associated with 15 of 16 phenotypes over-represented in the Transamidase+Remodeling Group and are in signaling cascades associated with lipid rafts which contain GPI-anchored proteins. *Numerous FGFs activate the FGFR2. Only FGF2 is known to be associated with lipid rafts (purple) [55,56,57,58]

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172