Fig. 2

Results of the GO-Term (a) and the in silico pathway analysis (b) of all significant regulated proteins utilizing the Proteomaps platform: a, b GO-Term analysis of all significant regulated proteins showing the 10 most significant up regulated (green) and down regulated (red) GO-Terms of the categories biological process and Molecular function. c Illustration of the in silico pathway analysis using Proteomaps for elevated proteins. (i) is showing all significant pathways affected by the individual proteins which are highlighted in (ii). d Illustration of the in silico pathway analysis using Proteomaps for downregulated proteins. (i) is showing all significant pathways affected by the individual proteins which are highlighted in (ii). The colour code refers to signalling (turquoise), genetic processing (blue), cellular processes (red), metabolism (orange), organismal systems (purple) and human diseases (black). e Comparison of the relative expression levels of Synaptopodin-2 measured in the whole protein extract (blue) and nuclear protein extract (red) of control and patient fibroblasts. Number of biological replicates of each condition was 4 (n = 4). Abbreviations: au (arbitrary units), ns (not significant)