Fig. 1

Genes profiled in the array organised by category. Ophthalmoplegic myasthenia gravis (OP-MG). “OP-MG genes” refers to genes identified by unbiased next generation sequencing analyses in OP-MG and control-MG subjects, either by whole genome sequencing (WGS) or whole exome sequencing (WES). “OP-MG pathways” refers to the main biological pathways associated with the known physiological functions of the putative OP-MG genes. The “atrophy signalling” genes were selected from biological pathways in reference 7 using associated KEGG pathways as resources. Ubiquitin proteasome system (UPS); experimental autoimmune myasthenia gravis (EAMG); acetylcholine receptor (AChR); muscle-specific kinase (MuSK); extracellular matrix (ECM). “Strabismus pathways” refers to genes with altered expression in human strabismic extraocular muscles. References in figure: (1) [5]; (2) [6]; (3) [50]; (4) [51]; (5) [12]; (6) [52]; (7) [32]; (8) [53]; (9) [18]; (10) [21]; (11) [22]; (12) [7]; (13) [54]