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Table 3 Correlation between MRI outcomes and pulmonary function tests outcomes

From: Chest MRI to diagnose early diaphragmatic weakness in Pompe disease

  FVC upright FVC supine Δ FVC MIP MEP
Thorax-related outcomes
Cranial-caudal ratio 0.518*** 0.680*** −0.654*** 0.435** 0.187
Anterior–posterior ratio 0.035 0.097 −0.112 −0.008 0.040
Lung area ratio 0.473*** 0.636*** −0.610*** 0.398** 0.151
CC-AP ratio 0.509*** 0.643*** −0.608*** 0.403** 0.161
Diaphragm-related outcomes
Diaphragm area ratio −0.556*** −0.588*** 0.484*** −0.355** −0.293*
Diaphragm height ratio −0.538*** −0.608*** 0.552*** −0.382** −0.270
Anterior displacement 0.089 0.201 −0.234 −0.065 −0.042
Posterior displacement 0.486*** 0.650*** −0.598*** 0.322* 0.021
  1. Spearman correlation coefficients between thorax-related outcomes and diaphragm-related outcomes (ratios between end-inspiration and end-expiration outcomes) and outcomes of pulmonary function tests (% predicted). Significant correlations are indicated with *p < 0.05, **p < 0.01 or ***p < 0.001
  2. CC-AP ratio = cranial caudal ratio / anterior posterior ratio. FVC = forced vital capacity, Δ FVC = FVC upright—FVC supine, MEP = mean expiratory pressure, MIP = mean inspiratory pressure