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Table 2 Uni- and multi-variate Cox regression analyses of survival

From: The prognostic role of plasma fibrinogen in adult secondary hemophagocytic lymphohistiocytosis

Characteristics Unadjusted Adjusted
HR (95% CI) P HR (95% CI) P
Male 0.85 (0.75–0.96) 0.010   
Age, years 1.00 (0.99–1.00) 0.009 1.00 (0.99–1.00) 0.017
ANC > 1.0 × 109/L 0.94 (0.84–1.06) 0.331   
HB < 90 g/L 0.87 (0.77–0.98) 0.027   
PLT < 100 × 109/L 0.76 (0.62–0.91) 0.004 0.81 (0.66–0.99) 0.043
LDH ≥ 2.5 × ULN 1.14 (0.93–1.39) 0.205   
TG ≥ 3.0 mmol/L 0.93 (0.82–1.05) 0.245   
Fever, ≥ 39.1 °C 1.02 (0.90–1.15) 0.775   
Splenomegaly 0.95 (0.78–1.16) 0.636   
Hemophagocytosis 1.08 (0.9–1.29) 0.403   
Log10 (Ferritin) 0.75 (0.66–0.85) < 0.001 0.78 (0.68–0.90) 0.001
Log10 (sCD25) 0.77 (0.65–0.92) 0.003   
EBV infection 0.78 (0.69–0.88) < 0.001 0.85 (0.74–0.96) 0.011
MHLH 0.78 (0.69–0.88) < 0.001 0.63 (0.54–0.74) < 0.001
Treatment
 Support treatment 1.00 (Ref.)   1.00 (Ref.)  
 GC + IVIG 0.90 (0.73–1.11) 0.323 1.08 (0.87–1.35) 0.462
 Chem ± HLH94 1.15 (0.93–1.40) 0.196 1.74 (1.38–2.22) < 0.001
FIB(g/L)
 3 st tertile 1.00 (Ref.)   1.00 (Ref.)  
 2 st tertile 1.03 (0.88–1.20) 0.726 1.06 (0.90–1.24) 0.486
 1 st tertile 0.76 (0.66–0.87) < 0.001 0.84 (0.71–0.98) 0.025
  1. Italics indicate statistical significance (P < 0.05)
  2. ANC absolute neutrophil count, HB hemoglobin, PLT platelet, LDH lactate dehydrogenase, TG triglyceride, sCD25 soluble interleukin-2 receptor, EBV Epstein-Barr virus, MHLH malignancy-associated haemophagocytic lymphohistiocytosis, GC glucocorticoid, IVIg intravenous immunoglobulins, FIB fibrinogen, HR hazard ratio, CI confidence interval