Week | Standard | Reduced dose | ||||
---|---|---|---|---|---|---|
 < 50 kg | 50–75 kg |  < 75 kg |  < 50 kg | 50–75 kg |  < 75–kg | |
 | Pulse | Pulse | Pulse | Pulse | Pulse | Pulse |
1 | 50 | 60 | 75 | 50 | 60 | 75 |
2 | 50 | 60 | 75 | 25 | 30 | 40 |
3–4 | 40 | 50 | 60 | 20 | 25 | 30 |
5–6 | 30 | 40 | 50 | 15 | 20 | 25 |
7–8 | 25 | 30 | 40 | 12.5 | 15 | 20 |
9–10 | 20 | 25 | 30 | 10 | 12.5 | 15 |
11–12 | 15 | 20 | 25 | 7.5 | 10 | 12.5 |
13–14 | 12.5 | 15 | 20 | 6 | 7.5 | 10 |
15–16 | 10 | 10 | 15 | 5 | 5 | 7.5 |
17–18 | 10 | 10 | 15 | 5 | 5 | 7.5 |
19–20 | 7.5 | 7.5 | 10 | 5 | 5 | 5 |
21–22 | 7.5 | 7.5 | 7.5 | 5 | 5 | 5 |
23–52 | 5 | 5 | 5 | 5 | 5 | 5 |
 > 52 | Investigators’ local practice | Investigators’ local practice |