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Table 3 Number of urinary extracellular vesicles (EVs) carrying cellular adhesion/inflammatory and renal injury molecules from primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Urinary EVs/mg creatinine Markers Primary Hyperoxaluria Type 1 (PH1) Statistical Results
PH1 without NC or KS
(n = 10)
PH1 with NC
(n = 6)
PH1 with KS
(n = 9)
p value Q value
Cellular adhesion/inflammatory markers ICAM-1 13.5 (12.0, 13.7) 12.2 (11.7, 12.7) 11.4 (11.0, 12.0) 0.02 0.13*
MCP-1 12.9 (12.3, 14.0) 12.5 (12.0, 12.8) 11.5 (11.3, 13.0) 0.13 0.17*
  Tissue factor 13.9 (13.2, 14.8) 13.4 (12.4, 14.50) 12.3 (12.2, 12.4) 0.02 0.13*
  VCAM-1 11.5 (10.0, 12.2) 10.7 (9.9, 11.0) 11.0 (10.2, 11.1) 0.73 0.73
Renal cellular injury markers β2-microglobulin 13.2 (12.8, 13.9) 12.8 (12.5, 13.5) 11.6 (11.5, 12.6) 0.12 0.17*
Clusterin 14.0 (13.4, 14.6) 13.0 (11.8, 14.1) 12.7 (11.8, 13.7) 0.19 0.23
KIM-1 12.9 (11.5, 14.1) 11.0 (10.2, 12.5) 11.3 (10.9, 13.0) 0.22 0.25
Laminin α5 14.0 (13.1, 14.2) 13.3 (12.5, 13.6) 12.6 (12.0, 13.0) 0.09 0.16*
NGAL 14.2 (13.1, 15.0) 12.7 (11.9, 13.7) 12.2 (11.6, 13.7) 0.07 0.15*
  1. Data are presented as median (25th and 75th percentile) of natural log of respective markers positive for urinary EVs/mg creatinine
  2. *False discovery rate (FDR) Q-value < 0.20 among PH1 patients groups