Table 3 Number of urinary extracellular vesicles (EVs) carrying cellular adhesion/inflammatory and renal injury molecules from primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)
Urinary EVs/mg creatinine | Markers | Primary Hyperoxaluria Type 1 (PH1) | Statistical Results | |||
|---|---|---|---|---|---|---|
PH1 without NC or KS (n = 10) | PH1 with NC (n = 6) | PH1 with KS (n = 9) | p value | Q value | ||
Cellular adhesion/inflammatory markers | ICAM-1 | 13.5 (12.0, 13.7) | 12.2 (11.7, 12.7) | 11.4 (11.0, 12.0) | 0.02 | 0.13* |
MCP-1 | 12.9 (12.3, 14.0) | 12.5 (12.0, 12.8) | 11.5 (11.3, 13.0) | 0.13 | 0.17* | |
|  | Tissue factor | 13.9 (13.2, 14.8) | 13.4 (12.4, 14.50) | 12.3 (12.2, 12.4) | 0.02 | 0.13* |
|  | VCAM-1 | 11.5 (10.0, 12.2) | 10.7 (9.9, 11.0) | 11.0 (10.2, 11.1) | 0.73 | 0.73 |
Renal cellular injury markers | β2-microglobulin | 13.2 (12.8, 13.9) | 12.8 (12.5, 13.5) | 11.6 (11.5, 12.6) | 0.12 | 0.17* |
Clusterin | 14.0 (13.4, 14.6) | 13.0 (11.8, 14.1) | 12.7 (11.8, 13.7) | 0.19 | 0.23 | |
KIM-1 | 12.9 (11.5, 14.1) | 11.0 (10.2, 12.5) | 11.3 (10.9, 13.0) | 0.22 | 0.25 | |
Laminin α5 | 14.0 (13.1, 14.2) | 13.3 (12.5, 13.6) | 12.6 (12.0, 13.0) | 0.09 | 0.16* | |
NGAL | 14.2 (13.1, 15.0) | 12.7 (11.9, 13.7) | 12.2 (11.6, 13.7) | 0.07 | 0.15* | |