Fig. 4

Patient 7, Primary ameloblastic carcinoma: a Radiography showed bone destruction in the mandible. b–d Computed tomography (CT) showed expansive destruction of the mandible in the axial, coronal, and sagittal view. Uneven soft tissue density, bone segregation, and uneven enhancement were observed. The lymph nodes in neck region I, II, and III on both sides were enlarged. e Postoperative samples showed a mixed cystic-solid structure and polycystic type. f Hematoxylin and eosin staining showed the carcinogenesis of the ameloblastoma with squamous cell carcinoma. g Transplantation of fibular myocutaneous flaps was simultaneously performed after radical tumor resection. h, i BRAF-V600E mutation