Table 1 Statistically significant results from clinical studies

RSBQ

Percy, et al. (2017) [5]

TFT 200 mg/kg vs PLC

Clinical benefit was observed for patients treated by TFT (0.042^T)

CGI

Percy, et al. (2017) [5]

TFT 200 mg/kg vs PLC

Clinical benefit was observed for patients treated by TFT (0.029^T)

VAS

Percy, et al. (2017) [5]

TFT 200 mg/kg vs PLC

Clinical benefit was observed for patients treated by TFT (0.025^T)

O’Leary, et al. (2018) [6]

PLC-MCS vs MCS-PLC

Worsening of symptoms for patients treated by PLC-MCS (0.0211^T; 0.0111^W)

ADAMS

O’Leary, et al. (2018) [6]

PLC-MCS vs MCS-PLC

Worsening of symptoms for patients treated by PLC-MCS (0.5535^T; 0.0272^W)

EEG

O’Leary, et al. (2018) [6]

PLC-MCS vs MCS-PLC

Worsening of symptoms for patients treated by PLC-MCS (0.0208^T; 0.0110^W)

Gorbachevskaya, et al. (2001) [7]

CL vs UT

Clinical benefit was observed for patients treated with CL: lower value of LRP in alpha and beta bands (< 0.001^T; < 0.01^T), higher levels of LRP in the theta band (< 0.001^T)

Gorbachevskaya, et al. (2001) [7]

Before CL vs after CL

Improvement of the brain functional stage after treatment with CL: decrease of theta LRP in central and frontal regions (< 0.05^T; < 0.01^T), increase of beta activity LRP in the parietal region (< 0.05^T), restoration of occipital alpha rhythm (< 0.05^T)

ECG

Guideri, et al. (2005) [8]

ALC at BS vs ALC after 6 months

Clinical benefit was observed in patients treated with ALC: increase of total power (0.01^T), VLF (0.01^T), and LF (0.009^T)

Guideri, et al. (2005) [8]

UT at BS vs UT after 6 months

Decrease in heart rate variability was observed in UT: decrease of total power (0.04^T) and LF (0.05^T), and increase of QTcD (0.01^T)

Respiratory function

Percy, et al. (1994) [9]

NLT vs PLC

Positive effect of NLT was observed: higher awake min. O2 saturation value (0.03^T), less % time spent with disorganized breathing (0.02^T), higher end tidal carbon dioxide value (0.02^T)

Djukic, et al. (2016) [10]

Before glatiramer acetate 20 mg vs after

Improvement of respiratory function: decrease of breath hold index (0.004^T; 0.03^W) and breath hold time (0.007^T; 0.004^W)

Khwaja, et al. (2014) [11]

Pre MAD MCS vs post OLE

Improvement of respiratory function: improvement of apnea (0.012^T)

CSS

Maffei, et al. (2014) [12]

ω-3 PUFAs at BS vs ω-3 PUFAs after 6 months

Significant improvements were observed: decrease in score for CSS (< 0.005^A), ambulation (0.02^A), hand use (0.002^A), motor (0.009^A), non-verbal communication (0.002^A), and respiratory dysfunction (< 0.0001^A)