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Table 2 Laboratory findings at diagnosis in clinically-detected and screen-detected patients with type 1 tyrosinemia

From: Type 1 tyrosinemia in Finland: a nationwide study

  Clinically-detected, n = 18 Screen-detected, n = 4 P value
na Median Range na Median Range
Age, months 18 6 2–36 4 1 0–31 0.098
AFP, kU/l 16 148,725 5990–420,800 4 82,868 6470–487,300 0.682
ALT, U/l 17 45 15–111 4 32 10–63 0.362
Calcium, mmol/l 15 2.15 1.26–2.70 4 2.60 2.34–2.60 0.014
Creatinine, μmol/l 14 25 12–103 4 27 24–32 0.327
DBil, μmol/l 12 17 6–38 4 5 3–11 0.013
γ-GT, U/l 14 136 43–328 4 99 91–134 0.327
NH4+ , μmol/l 15 74 36–141 4 65 38–87 0.530
Phosphate, mmol/l 16 0.86 0.22–2.64 4 1.85 0.77–2.19 0.064
PT,  % 16 11 0–37 4 35 15–68 0.029
TBil, μmol/l 17 30 16–48 4 61 14–106 0.144
Tyrosine, μmol/l 16 384 100–840 4 490 452–734 0.099
  1. AFP alpha-fetoprotein, ALT alanine aminotransferase, DBil conjugated bilirubin, γ-GT γ-glutamyl transferase, NH4+ ammonium ion, PT, prothrombin time, TBil total bilirubin
  2. aData available