Fig. 2

One patient’s pretreatment NCV (nerve conduction velocity) of the posterior tibial nerve improved and stayed stable within 2 years of mannose treatment (NCV reference of posterior tibial nerve > 40 m/s; blue dashed line; find nerve conduction velocity scale on the right in m/s). Improvement of the sialo-transferrin pattern was concordant to NCV development (blue area = tetrasialo-transferrin reference; find sialo-transferrin scale in % on the left). When mannose treatment was discontinued for this patient after 24 months (purple mark), the NCV of the posterior tibial nerve fell and stayed low for four more years without mannose