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Table 3 Compare HR-pQCT measurements pre- and six-month post- treatment of one representative patient (LJ004)

From: Bone mineral density and bone microarchitecture in a cohort of patients with Erdheim-Chester Disease

 

Pre-Tx Tibia

Post-Tx Tibia

Pre-Tx Radius

Post-Tx Radius

Geometric features

 Total area (mm2)

784.8

776.4

335.8

301.4

 Cortical area (mm2)

147.2

146.2

72.9

76.1

 Trabecular area (mm2)

643.3

635.9

267.1

229.1

Volumetric BMD

 Total BMD (mg/cm3)

350.7

361.1

310.1

337.7

 Trabecular BMD (mg/cm3)

223.7

228.5

145

134.8

 Cortical BMD (mg/cm3)

911.3

944.8

930.2

960.6

Microarchitecture measurements

 Trabecular BV/TV

0.326

0.328

0.204

0.189

 Trabecular number (1/mm)

1.885

1.462

1.467

1.516

 Trabecular thickness (mm)

0.305

0.322

0.216

0.216

 Trabecular spacing (mm)

0.536

0.696

0.647

0.637

 Standard deviation of 1/trabecular number

0.22

0.293

0.228

0.23

 Cortical thickness (mm)

1.58

1.616

1.123

1.247

 Cortical porosity (%)

0.01

0.01

0.007

0.004

  1. Abbreviations: BMD, bone mineral density; BV/TV, bone volume to tissue volume fraction;