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Table 3 Compare HR-pQCT measurements pre- and six-month post- treatment of one representative patient (LJ004)

From: Bone mineral density and bone microarchitecture in a cohort of patients with Erdheim-Chester Disease

  Pre-Tx Tibia Post-Tx Tibia Pre-Tx Radius Post-Tx Radius
Geometric features
 Total area (mm2) 784.8 776.4 335.8 301.4
 Cortical area (mm2) 147.2 146.2 72.9 76.1
 Trabecular area (mm2) 643.3 635.9 267.1 229.1
Volumetric BMD
 Total BMD (mg/cm3) 350.7 361.1 310.1 337.7
 Trabecular BMD (mg/cm3) 223.7 228.5 145 134.8
 Cortical BMD (mg/cm3) 911.3 944.8 930.2 960.6
Microarchitecture measurements
 Trabecular BV/TV 0.326 0.328 0.204 0.189
 Trabecular number (1/mm) 1.885 1.462 1.467 1.516
 Trabecular thickness (mm) 0.305 0.322 0.216 0.216
 Trabecular spacing (mm) 0.536 0.696 0.647 0.637
 Standard deviation of 1/trabecular number 0.22 0.293 0.228 0.23
 Cortical thickness (mm) 1.58 1.616 1.123 1.247
 Cortical porosity (%) 0.01 0.01 0.007 0.004
  1. Abbreviations: BMD, bone mineral density; BV/TV, bone volume to tissue volume fraction;