Table 3 Clinical features and time to diagnosis in the entire cohort and in the subgroups neurological vs non-neurological onset
From: Onset features and time to diagnosis in Friedreich’s Ataxia
Whole cohort | Neurological onset | Non-Neurological onset | p value | |
|---|---|---|---|---|
N (%) | 611 | 554 (90,7%) | 57 (9,3%) | |
Sex (women, %) | 286 (47%) | 259 (47%) | 27 (47%) | 0.96 |
Age at examination (years) | 31 (22;43) | 32 (23;43) | 28 (20;38) | 0.02 |
GAA1 (repeat number) | 620 (367;785) | 634 (367;785) | 585 (400;716) | 0.43 |
GAA2 (repeat number) | 912 (780;1050) | 912 (785;1050) | 890 (745;1050) | 0.44 |
Age at onset (years) | 13 (9;19) | 13 (9;20) | 12 (10;15) | 0.03 |
Late-onset (≥25 yo) (n. of cases) | 103 (17%) | 102 (18.4%) | 1 (1.7%) | 0.001 |
Time to diagnosis (years) | 3 (1;7) | 3 (1;6) | 5 (2;9) | 0.02 |