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Table 3 Clinical features and time to diagnosis in the entire cohort and in the subgroups neurological vs non-neurological onset

From: Onset features and time to diagnosis in Friedreich’s Ataxia

  Whole cohort Neurological onset Non-Neurological onset p value
N (%) 611 554 (90,7%) 57 (9,3%)  
Sex (women, %) 286 (47%) 259 (47%) 27 (47%) 0.96
Age at examination (years) 31 (22;43) 32 (23;43) 28 (20;38) 0.02
GAA1 (repeat number) 620 (367;785) 634 (367;785) 585 (400;716) 0.43
GAA2 (repeat number) 912 (780;1050) 912 (785;1050) 890 (745;1050) 0.44
Age at onset (years) 13 (9;19) 13 (9;20) 12 (10;15) 0.03
Late-onset (≥25 yo) (n. of cases) 103 (17%) 102 (18.4%) 1 (1.7%) 0.001
Time to diagnosis (years) 3 (1;7) 3 (1;6) 5 (2;9) 0.02
  1. Results of comparisons between the groups neurological vs non-neurological onset are reported in the last column. Categorical and continuous variables were compared by means of Chi-squared test und Mann Whitney-U test respectively. Statistically significant results are reported in bold.