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Table 3 Analysis of Baseline Frequency of Conduction Abnormalities in the NHS Cohort. Comparison of frequency of conduction abnormalities in the NHS cohort to the general population observed in Hingorani et al. Age groups are modified to be consistent. (*p < 0.02, **p < 0.00001)

From: Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva

  Hingorani et al. data NHS baseline data
  All subjects (n = 3978) (> 18 yr) 18–20 yr (n = 803) 21–45 yr (n = 2458) All subjects (n = 45) (> 18 yr) (18–20 yr) (n = 9) 21–45 yr (n = 35)
Conduction Abnormality 5.9% 5.9% 5.7% 22.2%** 22.2%** 22.9%**
Intraventricular Conduction Delay 2.3% 3.2% 2.1% 17.8%** 22.2%** 17.1%**
Right Bundle Branch Block (RBBB) 0.2% 0.0% 0.1% 0% 0% 0%
Incomplete Right Bundle Branch Block (IRBBB) 0.2% 0.5% 0.0% 2.2%* 0% 2.9%**
AV Block First Degree 2.2% 0.5% 2.2% 2.2% 0% 2.9%
  1. *p = 0.004 **p < 0.00001