Table 2 Summary of clinical features observed between severe Hb S/β+, Hb S/β0 and Hb SS groups
Clinical feature/Complication | severe Hb S/β+ group n = 37 | Hb S/β0 group n = 14 | Hb SS group n = 9 | Cumulative Figure N = 60 | p value1 between two SBT groups | p value2 between all three groups |
|---|---|---|---|---|---|---|
Joint pain | 20 (54.05%) | 12 (85.70%) | 7 (77.78%) | 39 (65.0%) | 0.053 | 0.080 |
Palpable spleen | 26 (70.27%) | 7 (50.0%) | 3 (33.33%) | 36 (60.0%) | 0.204 | 0.086 |
Hospital admission due to pain | 20 (54.05%) | 10 (71.43%) | 5 (55.56%) | 35 (58.33%) | 0.346 | 0.562 |
Jaundice | 14 (37.84%) | 9 (64.28%) | 6 (66.67%) | 29 (48.33%) | 0.120 | 0.109 |
Major infections | 13 (35.14%) | 4 (28.57%) | 4 (44.44%) | 21 (35.0%) | 0.749 | 0.744 |
Recurrent headaches | 11 (29.73%) | 1 (7.14%) | 2 (22.22%) | 14 (23.33%) | 0.142 | 0.281 |
Pica | 6 (16.22%) | 3 (21.43%) | 2 (22.22%) | 11 (18.33%) | 0.692 | 0.711 |
Abdominal pain | 6 (16.22%) | 4 (28.57%) | 0 | 10 (16.67%) | 0.432 | 0.217 |
Dactylitis | 3 (8.11%) | 3 (21.43%) | 4 (44.44%) | 10 (16.67%) | 0.327 | 0.027* |
Gallstones | 6 (16.22%) | 3 (21.43%) | 1 (11.11%) | 10 (16.67%) | 0.692 | 0.888 |
Pallor | 4 (10.81%) | 2 (14.28%) | 3 (33.33%) | 9 (15.0%) | 0.661 | 0.220 |
Acute chest syndrome | 3 (8.11%) | 3 (21.43%) | 2 (22.22%) | 8 (13.33%) | 0.327 | 0.290 |
Vision impairment | 8 (21.62%) | 0 | 0 | 8 (13.33%) | 0.088 | 0.074 |
Abdominal distension | 3 (8.11%) | 1 (7.14%) | 1 (11.11%) | 5 (8.33%) | 1.000 | 1.000 |
Facial deformities | 1 (2.70%) | 2 (14.28%) | 0 | 3 (5.0%) | 0.179 | 0.189 |
Nocturnal enuresis | 2 (5.40%) | 1 (7.14%) | 0 | 3 (5.0%) | 1.000 | 1.000 |
Leg ulcers | 2 (5.40%) | 1 (7.14%) | 0 | 3 (5.0%) | 1.000 | 1.000 |