Table 1 Haematological parameters of Hb SS, Hb S/β+ severe and Hb S/β0 type patients
Parameter | Hb SS | Hb S/β+ (severe) (n = 31) | Hb S/β0 (n = 11) | p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Mean (SD) | Mean (SD) | Mean (SD) | ||||||||
Male (n = 4) | Female (n = 2) | Total | Male (n = 16) | Female (n = 15) | Total | Male (n = 5) | Female (n = 6) | Total | ||
Hb (g/dl) (13.0–18.0 – Male) (11.5–16.5 Female) | 8.4 (1.1) | 8.7 (0.2) | 8.5 (0.9) | 8.3 (1.0) | 8.3 (1.0) | 8.3 (1.0) | 8.0 (0.8) | 8.3 (0.6) | 8.1 (0.7) | 0.787 |
Hb A2 (%) (1.5–3.2%) | 1.7 (0.4) | 1.4 (0.5) | 1.6 (0.4) | 4.4 (0.6) | 4.2 (0.5) | 4.3 (0.5) | 4.9 (0.2) | 4.4 (0.6) | 4.6 (0.5) | < 0.000* |
Hb F (%) (< 1.0%) | 20.6 (1.8) | 31.9 (0.5) | 24.4 (6.0) | 23.2 (6.4) | 24.3 (6.4) | 23.7 (6.4) | 19.1 (5.7) | 22.9 (8.7) | 21.2 (7.4) | 0.514 |
MCV (fl) (80–100) | 84.2 (4.3) | 85.0 (9.9) | 84.5 (5.6) | 69.3 (4.6) | 68.2 (3.9) | 68.8 (4.3) | 67.8 (3.3) | 69.2 (4.1) | 68.6 (3.7) | 0.001* |
MCH (pg) (27–32) | 29.6 (0.5) | 29.9 (2.0) | 29.7 (1.0) | 22.1 (1.7) | 22.3 (1.4) | 22.2 (1.6) | 21.0 (1.6) | 22.0 (1.3) | 21.5 (1.4) | < 0.000* |
MCHC (%) (33–35) | 33.0 (0.5) | 33.5 (0.7) | 33.2 (0.6) | 31.4 (0.8) | 31.6 (1.0) | 31.5 (0.9) | 31.7 (1.1) | 31.5 (0.6) | 31.6 (0.8) | 0.002* |
Reticulocytes (%) (0.5–1.5) | 9.6 (2.1) | 6.3 (5.5) | 8.5 (4.5) | 5.3 (1.6) | 5.1 (1.7) | 5.2 (1.6) | 4.8 (3.0) | 5.1 (2.4) | 5.0 (2.6) | 0.048* |
Absolute Retic count (×1012/L) (0.020–0.200) | 0.2767 (0.1041) | 0.1866 (0.1328) | 0.2467 (0.1104) | 0.2066 (0.0669) | 0.1905 (0.0609) | 0.1988 (0.0635) | 0.1643 (0.0856) | 0.1855 (0.0896) | 0.1759 (0.0840) | 0.244 |
WBC (× 109/L) (4.5–11.0) | 14.0 (8.8) | 6.7 (0.1) | 11.6 (7.8) | 8.7 (3.6) | 10.5 (5.6) | 9.59 (4.7) | 10.2 (5.5) | 12.2 (7.4) | 11.34 (6.4) | 0.863 |
PLT (× 103/μL) (150–450) | 324.0 (178.0) | 252.0 (111.8) | 300 (151.2) | 235.5 (155.0) | 330.3 (151.5) | 281.4 (158.3) | 254.6 (42.8) | 347.2 (199.5) | 305.1 (151.6) | 0.715 |