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Table 1 Haematological parameters of Hb SS, Hb S/β+ severe and Hb S/β0 type patients

From: Sickle cell disease in Sri Lanka: clinical and molecular basis and the unanswered questions about disease severity

Parameter Hb SS Hb S/β+ (severe) (n = 31) Hb S/β0 (n = 11) p-value
Mean (SD) Mean (SD) Mean (SD)
Male (n = 4) Female (n = 2) Total Male (n = 16) Female (n = 15) Total Male (n = 5) Female (n = 6) Total
Hb (g/dl)
(13.0–18.0 – Male)
(11.5–16.5 Female)
8.4 (1.1) 8.7 (0.2) 8.5 (0.9) 8.3 (1.0) 8.3 (1.0) 8.3 (1.0) 8.0 (0.8) 8.3 (0.6) 8.1 (0.7) 0.787
Hb A2 (%)
(1.5–3.2%)
1.7 (0.4) 1.4 (0.5) 1.6 (0.4) 4.4 (0.6) 4.2 (0.5) 4.3 (0.5) 4.9 (0.2) 4.4 (0.6) 4.6 (0.5) < 0.000*
Hb F (%)
(<  1.0%)
20.6 (1.8) 31.9 (0.5) 24.4 (6.0) 23.2 (6.4) 24.3 (6.4) 23.7 (6.4) 19.1 (5.7) 22.9 (8.7) 21.2 (7.4) 0.514
MCV (fl) (80–100) 84.2 (4.3) 85.0 (9.9) 84.5 (5.6) 69.3 (4.6) 68.2 (3.9) 68.8 (4.3) 67.8 (3.3) 69.2 (4.1) 68.6 (3.7) 0.001*
MCH (pg) (27–32) 29.6 (0.5) 29.9 (2.0) 29.7 (1.0) 22.1 (1.7) 22.3 (1.4) 22.2 (1.6) 21.0 (1.6) 22.0 (1.3) 21.5 (1.4) < 0.000*
MCHC (%) (33–35)  33.0 (0.5) 33.5 (0.7) 33.2 (0.6) 31.4 (0.8) 31.6 (1.0) 31.5 (0.9) 31.7 (1.1) 31.5 (0.6) 31.6
(0.8)
0.002*
Reticulocytes (%) (0.5–1.5) 9.6 (2.1) 6.3 (5.5) 8.5 (4.5) 5.3 (1.6) 5.1 (1.7) 5.2 (1.6) 4.8 (3.0) 5.1 (2.4) 5.0 (2.6) 0.048*
Absolute Retic count (×1012/L) (0.020–0.200) 0.2767 (0.1041) 0.1866 (0.1328) 0.2467 (0.1104) 0.2066 (0.0669) 0.1905 (0.0609) 0.1988 (0.0635) 0.1643 (0.0856) 0.1855 (0.0896) 0.1759 (0.0840) 0.244
WBC (× 109/L) (4.5–11.0) 14.0 (8.8) 6.7 (0.1) 11.6 (7.8) 8.7 (3.6) 10.5 (5.6) 9.59 (4.7) 10.2 (5.5) 12.2 (7.4) 11.34 (6.4) 0.863
PLT (× 103/μL) (150–450) 324.0 (178.0) 252.0 (111.8) 300 (151.2) 235.5 (155.0) 330.3 (151.5) 281.4 (158.3) 254.6 (42.8) 347.2 (199.5) 305.1 (151.6) 0.715
  1. Hb Haemoglobin, Hb A2 Adult Haemoglobin-2, Hb F Foetal Haemoglobin, MCV Mean Corpuscular Volume, MCH Mean Corpuscular Haemoglobin, MCHC Mean Corpuscular Haemoglobin Concentration, WBC White Blood Cells, PLT Platelets. p < 0.05 of Kruskal Wallis H test was taken as significant
  2. p value has been calculated with respect to total figures of the three groups (Hb SS, severe Hb S/β+ and Hb S/β0 type)