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Table 2 Body composition during the 3-year study

From: Three years of growth hormone treatment in young adults with Prader-Willi syndrome: sustained positive effects on body composition

 

At start

After 1 year

After 2 years

After 3 years

P-value*

Total group

 Total body FM% (SDS)

2.1 (1.9 to 2.3)

2.0 (1.9 to 2.2)

2.0 (1.8 to 2.1)

1.9 (1.8 to 2.1)

0.012

 Total body FM%

39.6 (36.7 to 42.6)

39.4 (36.7 to 42.1)

39.0 (36.4 to 41.6)

38.9 (36.2 to 41.6)

0.37

 Total body LBM (SDS)

−2.1 (−2.4 to −1.8)

− 2.0 (− 2.3 to − 1.7)

−1.9 (− 2.3 to − 1.6)

−1.9 (− 2.3 to − 1.6)

0.15

 Total body LBM (kg)

39.8 (37.4 to 42.2)

40.7 (38.4 to 43.0)

41.2 (38.8 to 43.5)

40.7 (38.4 to 43.0)

0.17

 BMI SDS

0.9 (0.5 to 1.3)

0.9 (0.5 to 1.3)

0.9 (0.5 to 1.3)

0.9 (0.5 to 1.2)

0.60

 BMI PWS SDS

−1.6 (−1.9 to − 1.2)

−1.6 (− 2.0 to − 1.2)

−1.7 (− 2.0 to − 1.3)

−1.7 (− 2.1 to − 1.3)

0.08

 IGF-I SDS

1.3 (1.0 to 1.6)

1.5 (1.1 to 1.9)

1.2 (0.8 to 1.6)

1.2 (0.8 to 1.6)

0.49

  1. Data are expressed as estimated means (95% CI). FM SDS, FM% SDS and LBM SDS were calculated according to age- and sex-matched Dutch references [25]
  2. *P-value of the change during 3 years of GH treatment