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Table 2 Body composition during the 3-year study

From: Three years of growth hormone treatment in young adults with Prader-Willi syndrome: sustained positive effects on body composition

 At startAfter 1 yearAfter 2 yearsAfter 3 yearsP-value*
Total group
 Total body FM% (SDS)2.1 (1.9 to 2.3)2.0 (1.9 to 2.2)2.0 (1.8 to 2.1)1.9 (1.8 to 2.1)0.012
 Total body FM%39.6 (36.7 to 42.6)39.4 (36.7 to 42.1)39.0 (36.4 to 41.6)38.9 (36.2 to 41.6)0.37
 Total body LBM (SDS)−2.1 (−2.4 to −1.8)− 2.0 (− 2.3 to − 1.7)−1.9 (− 2.3 to − 1.6)−1.9 (− 2.3 to − 1.6)0.15
 Total body LBM (kg)39.8 (37.4 to 42.2)40.7 (38.4 to 43.0)41.2 (38.8 to 43.5)40.7 (38.4 to 43.0)0.17
 BMI SDS0.9 (0.5 to 1.3)0.9 (0.5 to 1.3)0.9 (0.5 to 1.3)0.9 (0.5 to 1.2)0.60
 BMI PWS SDS−1.6 (−1.9 to − 1.2)−1.6 (− 2.0 to − 1.2)−1.7 (− 2.0 to − 1.3)−1.7 (− 2.1 to − 1.3)0.08
 IGF-I SDS1.3 (1.0 to 1.6)1.5 (1.1 to 1.9)1.2 (0.8 to 1.6)1.2 (0.8 to 1.6)0.49
  1. Data are expressed as estimated means (95% CI). FM SDS, FM% SDS and LBM SDS were calculated according to age- and sex-matched Dutch references [25]
  2. *P-value of the change during 3 years of GH treatment