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Table 1 Clinical characteristics at start of 3-year study

From: Three years of growth hormone treatment in young adults with Prader-Willi syndrome: sustained positive effects on body composition

 

Total group

Number (females)

43 (25)

Genetic subtype

 Deletion / mUPD / ICD / translocation

18 / 20 / 4 /1

Age at start of childhood GH treatment (yrs)

7.6 (5.2 to 10.1)

Age at inclusion (yrs)

 - Males

19.5 (18.7 to 20.7)

 - Females

18.4 (16.9 to 20.8)

Adult height (SDS)

−1.0 (− 1.7 to − 0.3)

BMI (kg/m2)

24.5 (21.9 to 27.7)

BMI for age (SDS)

0.9 (0.0 to 1.8)

BMI for PWS (SDS)

−1.4 (−2.0 to −0.7)

Fat mass percentage (SDS)a

2.2 (1.7 to 2.5)

Fat mass percentage (%)

40.9 (34.4 to 45.6)

Lean body mass (SDS)a

−2.3 (− 2.8 to −1.4)

GH-dose (mg/m2/day)

0.33 (0.33 to 0.59)

GH-dose (mg/kg/day)

0.012 (0.012 to 0.021)

IGF-I SDSa

1.5 (0.6 to 2.0)

  1. Data expressed as median (IQR)
  2. mUPD Maternal uniparental disomy, ICD Imprinting center defect, GH Growth hormone
  3. aFM% SDS, LBM SDS and IGF-I SDS were calculated according to age- and sex-matched Dutch references [25]