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Table 4 Associations Between T1/ECV Over Time and Changes in Myocardial Structure and Function

From: Prospective cardiovascular magnetic resonance imaging in adults with Alström syndrome: silent progression of diffuse interstitial fibrosis

Gradient in

T1 SAX Mid Gradient

T1 SAX Mid ECV Gradient

N

Rho

p-Value

N

Rho

p-Value

LVEDV Index (ml/m2)

26

0.019

0.927

24

−0.052

0.809

LVESV Index (ml/m2)

26

−0.444

0.023

24

−0.188

0.379

LVEF (%)

24

0.352

0.091

22

0.088

0.699

LV Mass Index (g/m2)

26

−0.056

0.784

24

0.203

0.340

LAV Biplane (ml/m2)

20

0.245

0.298

18

−0.377

0.123

GLS

25

0.422

0.036

23

0.024

0.914

GRS

23

0.268

0.217

21

0.116

0.618

E/A

22

−0.292

0.187

20

−0.029

0.905

E/e’ Average

23

−0.370

0.083

21

−0.268

0.241

HBA1c (mmol/mol)

24

−0.119

0.579

22

0.189

0.399

C-Peptide (pmol/L)

26

−0.101

0.624

24

−0.037

0.865

Pro NT BNP (ng/L)

26

−0.072

0.726

24

0.023

0.913

  1. For each of the markers considered, a linear regression model was produced for each patient, with the timing of the scan, relative to the first scan, set as a continuous covariate. Only those patients with at least two valid scans for the stated marker were included in the analysis. Spearman’s (rho) correlation coefficients were then produced between the resulting gradients. Bold p-values are significant at p < 0.05
  2. E/A mitral early filling (E)/atrial filling (A), E/e’, mitral early filling (E)/early myocardial relaxation velocity (e’), ECV extracellular volume, HbA1c glycated haemoglobin A1c, LAV left atrial volume, LV left ventricular, LVEDV index left ventricular end-diastolic volume indexed to body surface area, LVEF, left ventricular ejection fraction; LVESV index, left ventricular end-systolic volume indexed; NT-proBNP, serum Nterminal pro B natriuretic peptide; SAX, short axis
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172