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Table 4 Associations Between T1/ECV Over Time and Changes in Myocardial Structure and Function

From: Prospective cardiovascular magnetic resonance imaging in adults with Alström syndrome: silent progression of diffuse interstitial fibrosis

Gradient inT1 SAX Mid GradientT1 SAX Mid ECV Gradient
LVEDV Index (ml/m2)260.0190.92724−0.0520.809
LVESV Index (ml/m2)26−0.4440.02324−0.1880.379
LVEF (%)240.3520.091220.0880.699
LV Mass Index (g/m2)26−0.0560.784240.2030.340
LAV Biplane (ml/m2)200.2450.29818−0.3770.123
E/e’ Average23−0.3700.08321−0.2680.241
HBA1c (mmol/mol)24−0.1190.579220.1890.399
C-Peptide (pmol/L)26−0.1010.62424−0.0370.865
Pro NT BNP (ng/L)26−0.0720.726240.0230.913
  1. For each of the markers considered, a linear regression model was produced for each patient, with the timing of the scan, relative to the first scan, set as a continuous covariate. Only those patients with at least two valid scans for the stated marker were included in the analysis. Spearman’s (rho) correlation coefficients were then produced between the resulting gradients. Bold p-values are significant at p < 0.05
  2. E/A mitral early filling (E)/atrial filling (A), E/e’, mitral early filling (E)/early myocardial relaxation velocity (e’), ECV extracellular volume, HbA1c glycated haemoglobin A1c, LAV left atrial volume, LV left ventricular, LVEDV index left ventricular end-diastolic volume indexed to body surface area, LVEF, left ventricular ejection fraction; LVESV index, left ventricular end-systolic volume indexed; NT-proBNP, serum Nterminal pro B natriuretic peptide; SAX, short axis