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Table 3 Changes over time in markers

From: Prospective cardiovascular magnetic resonance imaging in adults with Alström syndrome: silent progression of diffuse interstitial fibrosis

 No. PatientsNo. ScansCorrelation AnalysisGEE Analysis
Rhop-ValueGradient (95% CI)p-Value
T1 SAX Basal (ms)301040.415< 0.00125.8 (20.0, 31.7)< 0.001
T1 SAX Mid (ms)301040.451< 0.00121.8 (17.4, 26.1)< 0.001
T1 SAX Basal ECV (%, pp)30940.1810.0811.4 (0.8, 2)< 0.001
T1 SAX Mid ECV (%, pp)30940.1920.0641.1 (0.6, 1.6)< 0.001
LVEDV Index (ml/m2)30106−0.1130.2470.04 (−0.60, 0.68)0.909
LVESV Index (ml/m2)30106−0.1640.0940.92 (−0.06, 1.90)0.067
LVEF (%, pp)301060.1040.289−0.27 (−1.23, 0.68)0.575
LV Mass Index (g/m2)301040.2570.0082.8 (1.9, 3.7)< 0.001
LAV Biplane (ml/m2)2960−0.2210.090−2.0 (−6.7, 2.7)0.409
GLS30950.0320.756− 0.04 (− 0.33, 0.26)0.809
GRS28860.0100.924−0.36 (−1.18, 0.47)0.394
E/A29720.1330.2672.3 (−2.2, 6.9)0.313
E/e’ Average30680.1610.1890.3 (−0.2, 0.8)0.299
HBA1c (mmol/mol)29100− 0.1160.250−0.9 (−2.5, 0.7)0.284
C-Peptide (pmol/L)3094−0.0280.788−90.7 (− 364.6, 183.2)0.516
NTpro BNP (ng/L)30105−0.1010.30634.4 (−33.9, 102.8)0.324
  1. Correlation analysis – results are from Spearman’s rho correlation coefficients between the marker and the timing of the scan, relative to the baseline scan
  2. GEE analysis - results are from generalised estimating equation models, as described in the methods. The “gradient” represents the average yearly change in the marker over the period
  3. Bold p-values are significant at p < 0.05. ECV and EF were measured as percentages, hence gradients represent percentage point (pp) increases
  4. E/A mitral early filling (E)/atrial filling (A), E/e’, mitral early filling (E)/early myocardial relaxation velocity (e’), ECV extracellular volume, HbA1c glycated haemoglobin A1c, LAV left atrial volume, LV left ventricular, LVEDV index, left ventricular end-diastolic volume indexed to body surface area, LVEF left ventricular ejection fraction, LVESV index, left ventricular end-systolic volume indexed, NT-proBNP serum Nterminal pro B natriuretic peptide; SAX, short axis