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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1

Fig. 1

Rapamycin inhibits HO in the natural course of FOP-ACVR1 mice. a. Schematic view of the experiments. Each treatment was initiated 7 days after DOX administration. b. Representative μCT images of vehicle-treated mice. Arrows indicate HO. c. Quantification of HO volume on Day 35. Vehicle group: n = 9, rapamycin group: n = 10; *, p < 0.05, Wilcoxon rank sum test. d. Kaplan-Meier survival curves of vehicle-treated (dotted line) and rapamycin-treated (solid line) FOP-ACVR1 mice. indicates the first day of treatment. Vehicle group: n = 9, rapamycin group: n = 10; p < 0.05, log rank test

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