Table 1 OI clinical nomenclature and estimated prevalence of OI types
From: Reproductive options for families at risk of Osteogenesis Imperfecta: a review
OI clinical type | Online Mendelian Inheritance in Man (OMIM) | Description of severity | |
|---|---|---|---|
OI 1 | 166,200 | Non-deforming mild OI with blue sclera | ~ 46–71% |
OI 2 | 166,210 | Perinatal lethal form of OI | ~ 12% |
OI 3 | 259,420 | Severe, progressively deforming OI | ~ 12–28% |
OI 4 | 166,220 | Common variable OI with normal sclera | ~ 12–28% |
OI 5 | 610,967 | OI with progressive calcification abnormalities | ~ 2–5% |