Sepsis | Fever, increased CRP, leukocytosis, positive blood cultures | Any severe EB subtype | [1,2,3] |
Acute feeding inability in newborns/infants | Feeding refusal, sialorrhea, blisters in the oral cavity | DEB | [4, 5] |
Acute airway obstruction | Shortness of breath, stridor, distress, dusky skin coloration | JEB | [6,7,8,9] |
Acute esophageal obstruction | Painful dysphagia, aphagia, sialorrhea, regurgitation | RDEB | [4, 10,11,12] |
Acute urinary retention | Inability to pass urine, lower abdominal distension and pain | JEB, DEB, KEB | [13,14,15,16] |
Corneal erosion | Pain, photophobia, blepharospasm, tearing | JEB, DEB, KEB | [5, 17,18,19,20,21] |