Fig. 1From: Developmental hypomyelination in Wolfram syndrome: new insights from neuroimaging and gene expression analysesA schematic representation of the endoplasmic reticulum and mitochondrial molecular changes in Wolfram syndrome (the red box indicate a deficiency of this protein). ER: endoplasmic reticulum; ATF6: Activating transcription factor 6; UPR: unfolded protein response; WFS1: wolframin protein; CISD2: CISD2 protein product, ERISBack to article page