| CTRL = 22 | Pre-HD = 15 | Chi-Square /Mann-Whitney |
---|
χ2/ U | p |
---|
| Gender (F:M) 15:7 | Gender (F:M) 8:7 | 0.836 | 0.361 |
| Handedness (R:L) 19:3 | Handedness (R:L) 15:0 | 3.058 | 0.383 |
| Median | IQR | Median | IQR | | |
Age (years) | 34 | 12 | 37 | 12 | 161.5 | 0.914 |
Education (years) | 11.5 | 2 | 12 | 7 | 155.5 | 0.766 |
CAG repeats | – | – | 41 | 2 | – | – |
Time to HD Onset (years) | – | – | 21.1 | 11 | – | – |
UHDRS - TMS | – | – | 1 | 3 | – | – |
UHDRS - OculoTMS | – | – | 0 | 1 | – | – |
UHDRS-TFC | – | – | 13 | 0 | – | – |
- No significant differences were found between Pre-HD and Controls in any of the Demographic variables
- IQR Interquartile Range, CAG repeats CAG repeat expansion confirmed by a genetic test, Time to HD Onset estimated number of years to the formal diagnosis of manifest HD, calculated with the Langbehn’s formula [58], UHDRS Unified Huntington’s Disease Rating Scale [59], TMS Total Motor Score of the UHDRS, OculoTMS a composite score extracted from the sum of the oculomotor items of UHDRS-Motor scale, TFC Total Functional Capacity scale of the UHDRS