Comparison of structural progression between ciliopathy and non-ciliopathy associated with autosomal recessive retinitis pigmentosa

Table 4 Rates of progression for the four measured parameters (EZ line width, horizontal, vertical diameters, and hyperautofluorescent ring area) for ciliopathy and non-ciliopathy patients

		OD			OS
		Change over time per year, Mean (sd)	p-value^*	p-value **	Change over time per year, Mean (sd)	p-value^*	p-value **	Difference in change, Mean (sd)
Horizontal diameter (μm)	Ciliopathy	−351 (239)	< 0.001	0.001	− 317 (208)	< 0.001	0.002	−34 (162)
Horizontal diameter (μm)	Non-ciliopathy	−117 (134)	0.005		−101 (163)	0.03		−15 (56)
Vertical diameter (μm)	Ciliopathy	- 348 (325)	< 0.001	0.11	− 319 (391)	0.003	0.01	−29 (428)
Vertical diameter (μm)	Non-ciliopathy	−163 (312)	0.06		−55 (38)	< 0.001		−108 (299)
Ring area (mm2)	Ciliopathy	−2.46 (2.64)	0.001	0.03	−2.48 (2.96)	0.002	0.01	0.03 (1.8)
Ring area (mm2)	Non-ciliopathy	−0.71 (1.63)	0.11		−0.47 (0.82)	0.045		− 0.24 (0.85)
EZ line width (μm)	Ciliopathy	−260 (162)	< 0.001	< 0.001	−295 (225)	< 0.001	0.001	35 (156)
EZ line width (μm)	Non-ciliopathy	−84 (81)	0.001		−88 (69)	< 0.001		3.6 (62)

* One sample t test for testing whether mean change over time is different from 0
** Two sample t test for comparing mean change over time between Ciliopathy vs. Non-ciliopathy

ISSN: 1750-1172