Fig. 1

Expression and activity of matrix metalloproteinases are increased in the lungs of HPS2 mice a) Transcript levels for Mmp-2, − 3, − 7, − 8, − 9, − 12, − 13 and − 14 in age-matched control and HPS2 mouse lungs (n = 4 each group, p < 0.05 vs control). b Western blot for MMP-2 and MMP-9 in whole lung digests from control and HPS2 mice. c Gelatin zymography for MMP-2 and MMP-9 in whole lung digests from control and HPS2 mice. d Western blot for MMP-2 and MMP-9 in bronchoalveolar lavage fluid from control and HPS2 mice. e Gelatin zymography for MMP-2 and MMP-9 in bronchoalveolar lavage fluid from control and HPS2 mice. Immunoblots are representative of at least two different blots and densitometry analyses (bar graphs) are representative n = 5 or more mouse specimens (*p < 0.05 HPS2 vs. control). Data are expressed as mean ± SE, and statistical significance was assessed using a Student’s unpaired t test or multiple comparisons