Table 2 Comparison of different mass spectrometric methods to detect variant TTRs in serum samples
Parameter | Direct MALDI (the present study) | |||
|---|---|---|---|---|
Immunoprecipitation | + | + | – | – |
ProteinChip system | – | – | + | – |
Running cost | Low | Low | High | Low |
Detection time | 2 days | 2 days | 3 h | 30 min |
Minimum mass difference that can be identified in each system | 14 Da | 13 Da | 15 Da | 12 Da |