Table 2 Comparison of different mass spectrometric methods to detect variant TTRs in serum samples
| Parameter | IP-ESI [10, 11] | IP-MALDI [7,8,9] | SELDI-TOF MS [13, 14] | Direct MALDI (the present study) |
|---|---|---|---|---|
| Immunoprecipitation | + | + | – | – |
| ProteinChip system | – | – | + | – |
| Running cost | Low | Low | High | Low |
| Detection time | 2 days | 2 days | 3 h | 30 min |
| Minimum mass difference that can be identified in each system | 14 Da | 13 Da | 15 Da | 12 Da |