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Table 2 Comparison of different mass spectrometric methods to detect variant TTRs in serum samples

From: New simple and quick method to analyze serum variant transthyretins: direct MALDI method for the screening of hereditary transthyretin amyloidosis

Parameter IP-ESI [10, 11] IP-MALDI [7,8,9] SELDI-TOF MS [13, 14] Direct MALDI (the present study)
Immunoprecipitation + +
ProteinChip system +
Running cost Low Low High Low
Detection time 2 days 2 days 3 h 30 min
Minimum mass difference that can be identified in each system 14 Da 13 Da 15 Da 12 Da