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Table 1 Clinical and laboratory characteristic of adults and children with LABD

From: Linear IgA bullous dermatosis in adults and children: a clinical and immunopathological study of 38 patients

Characteristic Adults (n = 27) Children (n = 11) p-value
Male patients 13 (48.1) 8 (72.7) 0.28
Mean age at diagnosis (years) 60.6 5.4
“String of pearls” pattern 3 (11.1) 5 (45.5) 0.03*
Mucosal involvement 4 (14.8) 5 (45.5) 0.09
Head involvement (excluded mucosae) 6 (22.2) 8 (72.7) 0.008*
Perioral involvement 1 (3.7) 6 (54.5) 0.001*
Scalp involvement 4 (14.8) 0 0.3
Limbs 20 (74.1) 8 (72.7) 0.93
Trunk 15 (55.6) 6 (54.5) 1
Buttocks 4 (14.8) 1 (9.1) 1
Drug-induction 1 (3.7) 1 (9.1) 0.5
Eosinophils on histopathology 17 (62.7) 5 (45.5) 0.47
Linear IgA along the BMZ at DIF 21 (77.8) 9 (81.8) 1
Linear/granular IgA along the BMZ at DIF 6 (22.2) 2 (9.1) 1
C3c deposits at DIF 7 (25.9) 4 (36.4) 0.7
Salt-split skin IIF positivity for linear IgAa 13 (43.5) 6 (85.7) 0.21
CRb 21 (84) 10 (90.9) 1
PRb 2 (8) 1 (9.1) 1
NRb 2 (8) 0 1
Relapsesb 4 (16) 1 (9.1) 1
  1. Values are expressed as n (%); C3c, complement fraction 3; CR, complete remission; DIF, direct immunofluorescence; IIF, indirect immunofluorescence; NR, no response; PR: partial remission; a, performed in only 30 patients (23 adults and 7 children); b, 2 patients lost at follow-up; *, statistically significant