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Table 2 Scores of the scales used to evaluate non-motor symptoms of Parkinson’s disease in patients with Gaucher disease type 1 and comorbidities found (n = 23)

From: Evaluation of the frequency of non-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1

Patient

BDI

ESS

UMSARS

SST

MoCa

RBD-1Q

MDS-UPDRS III

Comorbidities

1

4

6

0

10

30

N

0

Hyperparathyroidism

2

16

11

1

10

26

N

0

Lactating, low vitamin B12 level

3

4

9

0

11

28

N

0

Ulcerative colitis (treated with aminosalicylate), low vitamin B12 level

4

5

8

1

12

29

N

0

None

5

3

17

0

11

23

Y

0

Smoking

6

4

9

1

11

26

N

0

None

7

3

11

1

10

26

N

0

Pulmonary hypertension

8

2

8

1

9

26

Y

0

None

9

12

11

1

12

27

N

0

High blood pressure (treated with angiotensin receptor blockers and diuretics), low vitamin B12 level

10

0

18

0

12

26

Y

0

Smoking

11

6

13

1

12

26

N

0

Asthma, irritable bowel syndrome (treated with antidepressants, spasmolytics, and a beta blocker)

12

7

3

1

12

30

N

0

Smoking; hypertension (treated with beta blocker)

13

2

10

0

10

29

N

0

None

14

4

15

0

12

29

N

0

Cardiomyopathy (treated with beta blockers)

15

25

1

2

10

22

N

0

Smoking, depression (treated with tricyclic antidepressants)

16

33

7

0

11

22

N

0

None

17

6

NP

0

12

26

N

0

Insomnia, anxiety (treated with nonbenzodiazepine hypnotics and selective serotonin reuptake inhibitor), low vitamin B12 level

18 a

14

12

0

6

26

N

0

Hypertension (treated with angiotensin-converting enzyme inhibitors).

19 a

17

4

2

4

22

N

0

Hypertension (treated with calcium channel blockers and beta blocker), osteoporosis, rhinitis

20

13

12

1

10

20

N

27

Hepatocellular carcinoma, hypertension (treated with calcium channel blockers and beta blocker)

21

3

7

0

11

26

N

7

Stroke at age 55; hypertension (treated with calcium channel blockers, angiotensin receptor blockers, and beta blocker)

22

4

13

2

9

19

Y

0

Obesity, osteoporosis, arrhythmia, low vitamin B12 level

23

16

3

1

10

23

N

0

Depression (treated with selective serotonin reuptake inhibitor), hypertension (treated with angiotensin-converting enzyme inhibitor)

  1. Altered results are presented underlined. Bold type denotes patients who screened positive for more than one non-motor symptom of Parkinson’s disease. BDI Beck Depression Inventory (cutoff for depression > 14), ESS Epworth Sleepiness Scale (cutoff for increased daytime sleepiness > 10), UMSARS Unified Multiple System Atrophy Rating Scale (cutoff for constipation ≥2), SST Sniffin’ Sticks Test (cutoff for hyposmia < 9/12), MoCa Montreal Cognitive assessment (cutoff for cognitive impairment < 26), RBD-1Q Single-Question Screen for REM Sleep Behavior Disorder (cutoff being a positive answer to the single question), NP not performed, MDS-UPDRS III motor symptoms of PD assessed with part III of the Unified Parkinson’s Disease Rating Scale. Low vitamin B12 level < 200 pg/mL. aThese patients underwent clinical examination and fiberoptic nasopharyngoscopy by an ENT doctor
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172