Table 1 Outcomes before and after run-in medication (all patients)

 maximum dose

–

–

76%

29/38

–

–

 step 3 dose

–

–

18%

7/38

–

–

 step 2 dose

–

–

5%

2/38

–

–

Systolic blood pressure [mmHg]

111 ± 13

n = 41

102 ± 14

n = 38

−9 [−13 to −5]*

n = 37

 Left ventricle fractional shortening [%]

35 ± 3

n = 42

36 ± 4

n = 38

0 [−1 to 2]

n = 38

 Ventricular heart rate [beats/min]

97 ± 14

n = 41

88 ± 16

n = 38

−9 [−13 to −4]*

n = 37

 minimum

73 ± 10

n = 38

69 ± 11

n = 35

−2 [−6 to 2]

n = 34

 maximum

140 ± 15

n = 38

129 ± 15

n = 35

−11 [−16 to −6]*

n = 34

 mean

101 ± 13

n = 38

93 ± 11

n = 35

−8 [−13 to −3]*

n = 34

 mean NN [ms]

574 ± 122

n = 23

627 ± 140

n = 21

52 [24 to 81]*

n = 19

 SDNN [ms]

85 ± 23

n = 22

97 ± 29

n = 21

12 [3 to 21]*

n = 19

 SDANN [ms]

69 ± 24

n = 23

73 ± 24

n = 21

0 [−12 to 13]

n = 20

 ASDNN [ms]

45 ± 18

n = 22

57 ± 21

n = 21

11 [5 to 18]*

n = 19

 rMSSD [ms]

35 ± 18

n = 24

46 ± 23

n = 22

9 [−1 to 18]

n = 21

 pNN50 [%]

9 ± 8

n = 24

15 ± 13

n = 21

5 [1 to 10]*

n = 20