Table 5 Median age at first reported occurrence of manifestations/events considered to contribute to HPP clinical burden, by age at occurrence of first HPP manifestation
Manifestation/event | Median age at first manifestation of HPP, years (range) | ||||
|---|---|---|---|---|---|
In utero n = 30 | Infancy (0 to < 2 years) n = 102 | Childhood (2 to < 10 years) n = 78 | Adolescence (10 to < 18 years) n = 9 | Adulthood (≥ 18 years) n = 46 | |
Respiratory symptoms | 0.1 (0–0.8) | 0.4 (0–1) | N/A | N/A | N/A |
Cranial abnormalities | 1 (0–4) | 0.7 (0–12) | 5 (1–9) | N/A | N/A |
Pain | 1 (1–1) | 34 (0–50) | 40 (3–56) | 42 (10–57) | 51 (20–64) |
Surgery | 2 (0–3) | 2 (0.1–30) | 59 (1–59) | 44 (12–44) | 70 (32–83) |
Gross motor/ambulation difficulties | 2 (0.5–5) | 22 (0–54) | 18 (1–55) | 19 (19–19) | 89 (30–90) |
Premature loss of teeth | 3 (1–4) | 3 (0–24) | 5 (2–21) | 14 (13–17) | 25 (6–60) |
One or more fractures | 15 (0–15) | 38 (0–53) | 35 (2–55) | 53 (15–53) | 50 (19–75) |