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Table 2 Demographic/clinical characteristics and duration of follow-up of patients with ≥1 year of follow-up

From: Frequency and age at occurrence of clinical manifestations of disease in patients with hypophosphatasia: a systematic literature review

Characteristic Value
Total cases, n (%) 265 (100.0)
Male, n (%) 118 (44.5)
Median (IQR) age at anchor visit, yearsa 4.0 (0.4–34.0)
Reported family history of HPP, n (%) 74 (27.9)
Age at first reported occurrence of HPP manifestations, n (%)
In utero 30 (11.5)
Infancy/early childhood (<  2 years) 101 (38.7)
Childhood (2 to < 10 years) 78 (29.9)
Adolescence (10 to < 18 years) 9 (3.4)
Adulthood (≥ 18 years) 43 (16.5)
Median (IQR) duration of follow-up by age at first reported occurrence of HPP manifestations, years
Overall 7.0 (3.0–18.0)
In utero 4.0 (2.1–10.3)
Infancy/early childhood (<  2 years) 5.4 (2.4–14.8)
Childhood (2 to < 10 years) 7.7 (3.6–28.5)
Adolescence (10 to < 18 years) 6.0 (4.3–27.0)
Adulthood (≥ 18 years) 15.0 (6.3–27.0)
  1. All patients who had been followed longitudinally for at least 1 year were included in this analysis
  2. aAnchor visit: first presentation to author of the case report
  3. HPP hypophosphatasia, IQR interquartile range