Fig. 2

Approximate timelines of disease-related events in patients with MLD (a) Mean timing of events following symptom onset for patients with late-infantile MLD and juvenile MLD (b) Sample individual disease timeline for a patient with late-infantile MLD (c) Sample individual disease timeline for a patient with juvenile MLD. When parents reported an approximate timing within an acceptably short range (e.g. < 1 year), the midpoint was used. ‘n’ corresponds to the number of patients for whom information on the timing of the event was available. ^aWalking loss was defined as a complete loss of ability to walk either assisted or unassisted. For late-infantile MLD, 11 patients who never learned to walk were not included in walking loss estimates. ^bA functional loss was defined as a complete loss of a gross motor function, a fine motor or related function, or speech. G-tube, gastrostomy tube