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Table 1 Mutation, TNM, surgery, Ki-67 (%) of the largest tumor, and follow-up of 6 MEN-1 patients

From: Intertumor heterogeneity in 60 pancreatic neuroendocrine tumors associated with multiple endocrine neoplasia type 1

Patient Mutation Gender Age T N M Ki-67% function Surgery Follow-up
Status
Years
ENETS UICC
A Exon 2, del 4 bp (c.247_250delCTGT);
- > Termination after amino acid 116
m 29 3 2 0 0 2 F (WDHA-Syndrome) TP DF 12
B Intron 4, G > A -9 bp
- > Alternative splicing
f 60 2 2 1 0 8 NF TP PD (M?) 10
C Exon 9, Q405X, CAG > TAG (Gln > Stop)
- > Termination after amino acid 404
m 60 2 2 0 0 2 NF TP DF 7
D Exon 3, Codon 179 GAG>AAG (Glu > Lys)
- > AS Exchange
m 15 2 1 0 0 3 F (Hyper-insulinism) DP DF 29
E Exon 4, p.I247N, ATT > AAT (Ile > Asn)
WORLDWIDE INDEX-CASE
f 38 2 2 0 0 1 NF TP DF [+] 4
F Exon 3, del4bp (amino acid 210/211)
- > Termination after amino acid 209
m 33 3 2 1 0 1 F (subclinical Hyper-insulinism) DP, E PD (N) 21
  1. T tumor classification of the largest tumor, N lymph node, Ki-67 Index in %, M distant metastasis, m male, f female
  2. F functioning, NF non-functioning
  3. TP fotal pancreatectomy, DP distal pancreatic resection, E enucleation
  4. DF disease free, PD pogressive disease; [+]: died unrelated to MEN-1