Table 4 Urinary ALA and PBG excretion according to genotype
Gene | Genotype | U-PBG/Cr | U-ALA/Cr | ||||
|---|---|---|---|---|---|---|---|
mean (SE) | beta (CI 95%) | P value | mean (SE) | beta (CI 95%) | P value | ||
CYP2C9 | two normal alleles | 12.93 (3.36) | −3.82 (−9.25;-1.62) | 0.163 | 8.48 (1.30) | −1.26 (−8.07;5.55) | 0.711 |
one allele *2 or *3 | 5.62 (1.88) | 12.85 (6.67) | |||||
two alleles *2 or *3 | 1.87 (0.80) | 4.98 (0.71) | |||||
CYP2C19 | two normal alleles | 9.12 (2.34) | −1.84 (− 10.11; 6.43) | 0.655 | 10.58 (3.01) | −3.96 (− 14.03;6.11) | 0.432 |
one allele *2 | 9.32 (4.27) | 6.39 (1.30) | |||||
two alleles *2 | NA | NA | |||||
CYP2D6 | two normal alleles | 10.71 (2.63) | −0.67 (−8.60; 7.27) | 0.866 | 10.45 (2.94) | −3.69 (−13.34;5.96) | 0.444 |
one allele *4 or *5 | 5.34 (2.38) | 5.93 (1.05) | |||||
two alleles *4 or *5 | 0.76 (NA) | 11.82 (NA) | |||||
CYP3A4 | two normal alleles | 9.52 (2.12) | −7.11 (−25.30;11.09) | 0.435 | 9.67 (2.27) | −6.72 (−29.08;15.65) | 0.547 |
one allele *1B | 1.88 (1.07) | 2.96 (1.56) | |||||
two alleles *1B | NA | NA | |||||
CYP3A5 | two normal alleles | NA | 2.54 (−10.64;15.72) | 0.699 | NA | 5.46 (−10.63;21.54) | 0.497 |
one allele *3 | 6.45 (5.00) | 4.33 (1.02) | |||||
two alleles *3 | 9.45 (2.2) | 9.86 (2.38) | |||||