Fig. 6
From: FGF23 and its role in X-linked hypophosphatemia-related morbidity
FGF23 and kidney abnormalities. Elevated levels of FGF23 in XLH increase renal expression of TRPV5 calcium channels, contributing to local excesses of calcium and general hypercalcemia, which may contribute to enthesopathies and calcification of arteries, resulting in hypertension and cardiovascular disease. Although nephrocalcinosis occurs in XLH as a side-effect of conventional therapy, the TRPV5-mediated increase in renal calcium absorption may play a permissive role